Nanochannels and nanopores for DNA analysis

The last decade has seen the advent of nanometer-scale fluidic channels and pores which use electric fields to control and analyze DNA. For example, the impedance of these channels can be monitored by measuring the current associated with translocation of DNA through nanopores. Our lab is conducting basic studies of these phenomena including concentration polarization (formation of ion-depleted and ion-enriched regions on either side of a nanochannel) and the dynamics of electrophoretic migration of DNA.

References

Kunlin Ma, Ashwin Ramachandran, and Juan G. Santiago. "Analytical solutions for viscoelectric effects in electrokinetic nanochannels" Electrophoresis (2024): 1-11.

Thomas A. Zangle, Ali Mani, and Juan G. Santiago. "Theory and experiments of concentration polarization and ion focusing at microchannel and nanochannel interfaces" Chemical Society Reviews 39, no. 3 (2010): 1014-1035.

Ali Mani, Thomas A. Zangle, and Juan G. Santiago. "On the propagation of concentration polarization from microchannel− nanochannel interfaces Part I: analytical model and characteristic analysis" Langmuir 25, no. 6 (2009): 3898-3908.